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Extensive evidence suggests that defects in the process of selective autophagy of dysfunctional mitochondria contribute to neurodegeneration (Fivenson et al., It also is important to take into account the epigenetic mechanisms that contribute to the development of neurodegenerative diseases, such as DNA methylation, changes in chromatin structure, mainly due to histone acetylation, ubiquitination, and phosphorylation mechanisms, as well as non-coding ribonucleic acids (micro-RNAs

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To avoid such side effects, the VIC supplementation should not exceed the tolerable upper intake levels (Table 2)

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