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However, the significance of this effect is unclear as the authors did not include comparator groups without dextran sulfate sodium treatment, which would be needed meaningfully assess the effect of the treatment on circadian rhythmicity

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Among the multiple effects of klotho, we have to comment in relation to this review, the effect of klotho on pituitary GH secretion

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502,503 Moreover, the pseudouridylation of mt-tRNA-derived fragments is also affected by PUS1 mutations, further contributing to defective mitochondrial protein synthesis

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