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Mice were chronically exposed to filtered air for control group or to CS (20 cigarettestwice/day, 6 days/week) from Marlboro cigarettes (Philip Morris Companies, 0.8 mg of nicotine, 10 mg of tar, and 10 mg of carbon monoxide per cigarette) for the other groups

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Your stomach breaks down oral supplements, and this can prevent adequate amounts of vitamin B12 to be absorbed into your system