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Nutritional prevention of cognitive decline and dementia

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Ruppert PM, Deng L, Hooiveld GJ, Hangelbroek RW, Zeigerer A, Kersten S

In a STZ-induced DN rat model, BBR alleviated renal damage by reducing fasting blood glucose levels, kidney-to-body weight ratio, 24-h proteinuria, creatinine (Cr) and blood urea nitrogen (BUN) concentrations

The distal promoter region contains several CAAT boxes and TATA-like sequences, as well as binding sites for nuclear factor 1 (NF-1), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B), CCAAT/enhancer binding protein (C/EBP), the glucocorticoid receptor (GR), and activating protein 1 (AP-1) (101)