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Su, C.-F., Jiang, L., Zhang, X.-W., Iyaswamy, A

Strikingly, we find that the disordered FOXO4-DRI binds to the disordered p53 TAD2 and forms a transiently folded complex

Summary Keywords CPT II deficiency, carnitine, fatty acid oxidation, polycystic kidneys, ventriculomegaly Citation Tan YY, Tewani KG, Anand AJ, Kong CX, Rajadurai VS and Chandran S (2025) Case Report: Lethal neonatal form of CPT II deficiency in consecutive pregnancies: fetal-neonatal characteristics, biochemical and molecular review

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The position of GSH in the model is supported by data showing that mutation of two of the arginines, R73 and R74, results in complete loss of substrate saturation with GSH (with CDNB as the electrophilic second substrate)