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Discussion To identify emerging senolytics, we screened a library of electrophilic compounds, which can target proteins through covalent bond formation

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Although pH values lower than 6.5 exhibit increased SGE formation in UGT74F2, they have no effect on SGE formation by UGT74F1 and, vice versa, at pH values higher than 6.5 SAG formation by UGT74F1 increases but is unchanged in UGT74F2

Specifically, the surface of the gastrointestinal tract is covered by a mucous layer about 50450 m thick, with a pore size of about 501800 nm and a negative charge, forming a complex physicochemical barrier ( Chitosan can enhance the transepithelial permeability of anticancer drugs by temporarily opening tight junctions between epithelial cells ( The carboxyl group on the alginate molecular chain can electrostatically interact with the positively charged protein in the colon mucosa to form a hydrophilic adsorption layer (Figure 2B)

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