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Shang et al[16]

The peak area ratios of the pure quinones and quinones after reacting with GSH in different concentration ratios (quinones: GSH = 1:1, 2:1, and 4:1) were measured by LC-MS and used for calculated reaction efficiency (RE)

They also report a low rate of tympanic membrane perforations following the intratympanic delivery (0.9%) [123]

3.5 Renin-angiotensin-aldosterone system In DKD, the activation of renin-angiotensin-aldosterone system (RAAS) is commonly observed and contributes to the progression of DKD

Depending on preference and expectation, it can be either way while delivering relatively similar effects

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