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MS scan parameters were as follows: scan type: full MS, scan range: 69.01,000 m/z, resolution: 70,000, polarity: positive and negative, alternating, AGC-target: 3 10 6 , maximum injection time: 200 ms HESI

Published phase 3 trials including OASIS 1 (Knop et al., 2023) show that even low absolute bioavailability can be clinically meaningful if the drug is potent enough and the dose is calibrated accordingly

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Aicher A , Heeschen C , Mohaupt M , Cooke JP , Zeiher AM , Dimmeler S

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XM assisted in the collection of data and edited the manuscript