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Limitations of the Research Despite promising animal studies, key limitations remain: Human studies are sparse: Most research is conducted in rodents with few clinical trials

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See this NAD+ bioavailability study in Cell Metabolism

end points for phase III trials might not be the same as those used for phase II trials

It also appeared that BPC-157 may have regulated the phosphorylation level of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and their downstream targets, including c-Fos, c-Jun, and Egr-1