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As such, evaluat- ing the ROS- modulating and immunomodulatory capacities of FIGUR E | Gene expression levels of IL- 1, TNF- , MMP13, IGF1, VEGF, IL- 6, and COL1A1 in L929 cells following 1- , 3- , and 7- day in- cubation with Gel7.5- CZG, Gel10- CZG, and Gel15- CZG hydrogels

Perhaps the most compelling evidence that inflammation plays a causal role in depression comes from immunotherapy studies, where administration of IFN- or IL-2 for treatment of cancer or hepatitis C induces symptoms of depression in a time- and dose-dependent manner [269, 270]

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