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PMID: 111 ZhengNLiaoTZhangCZhangZYanSXiXet al

Early in therapy, elevations in aminotransferases have been linked to higher levels of methyl-mercaptopurine, a metabolite formed during AZA biotransformation and known to exert direct toxic effects on hepatocytes [29, 30]

298 COVID-19 is primarily caused by respiratory viruses, and the pulmonary microbiome contributes to the development of severe pneumonia by promoting inflammatory responses and regulating cytokines

They include tremors, difficulty speaking and swallowing, drooling, incoordination, involuntary jerky movements (chorea), personality changes, and even psychosis (such as schizophrenia or manic-depressive illness)

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Integrating genetic data with robust clinical variables and machine learning approaches can improve prediction, with some models explaining up to 13.7% of the variance in lithium response, but these require further validation [4, 23, 82]