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doi: 10.3389/fonc.2018.00367 23 Brahimi-HornCBerraEPouyssegurJ

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Moreover, several studies highlight the strain-specific nature of these effects, underscoring the importance of identifying and characterizing individual probiotic strains for therapeutic use

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Chemotherapeutic agents, ionizing radiation, metabolites, and replication stresses cause continual DNA damage, which if repaired incorrectly may lead to somatic mutations and thus cell transformation or, if accumulated, can result in constant activation of the DNA damage response (DDR) and cause senescence