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it also recommends that people over 50 receive half the RDA from fortified foods or supplements because that form of B12 is not bound to protein and is easier to absorb (IOM, 1998)

When oral B12 may be used Oral B12 may be appropriate for many people who need general supplementation or who have mild deficiency

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The severity of vitamin B12 deficiency may depend heavily on the age of the patient and how long one has been taking metformin

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Research suggests it has a relatively mild safety profile, but long-term safety studies are still limited