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This transport dissipates any concentration gradient between cytoplasm and mitochondrial whose concentrations are both * 5 mM

This can promote further inflammation and excessive levels of pro-inflammatory mediators

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As a consequence, both the absolute concentration of GSH and GSSG as well as their ratio may be changed, thus means to monitor and quantify GSH oxidation during both cell lysis/extraction and organelle isolation need to be established and implemented

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