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This includes the upregulation of ferritin heavy and light chain, ferroportin, transferrin receptor and heme oxygenase-1 (HO-1), alongside increased production of NADPH, GSH and CoQ10 (coenzyme Q10) which counter lipid peroxidation and suppress ferroptosis (66,67)

Our findings are consistent with other studies showing that acute neuroendocrine stressors suppress antioxidant defenses in the brain of zebrafish 13 as well as in rodents showing a decrease in antioxidant levels in both plasma and the brain 55,59,60

This conjugation was also used in small interfering RNA delivery by LNP as asthma treatment 227

Randomized controlled trial of oral glutathione supplementation on body stores of glutathione in healthy adults

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