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En monos rhesus mayores, se inform que Epitalon aumentaba la produccin de melatonina por la noche y normalizaba el ritmo diario del cortisol

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There is upregulation of HIF- signaling in tissue hypoxia

While this challenge is inherent to all Fc-containing ADCs, the dual-targeting nature of BsADCs necessitates particularly careful optimization of Fc function to balance potential efficacy (e.g., ADCC) against the risk of off-target toxicity