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This study was supported by the Traditional Chinese Medicine Inheritance and Innovation Talent Project (Zhongjing Project) (CZ0325-10), 2022 Henan Provincial Special Research Project for Top-Notch Traditional Chinese Medicine Talent Cultivation(2022ZYBJ09), Henan Provincial Traditional Chinese Medicine Research Grant (Grant No

Finally, the model predicts that p62 knock-down by siSQSTM1 yields lower base levels of Keap1-GFP in the autophagosome and also lower levels upon DEM treatment relative to the siCtrl condition (Fig 3C