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REIMAGINE 3 was a 40-week efficacy and safety phase 3 trial of CagriSema 2.4 mg/2.4 mg and 1 mg/1 mg once-weekly versus placebo in 274 adults with type 2 diabetes as add-on to once-daily basal insulin with or without metformin

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It includes 25P/28P/29P mutations to reduce the proteins propensity to form fibrils and -sheets and the insertion of a C-terminal proline improves binding to the CTR channel

Similar content being viewed by others Introduction Cancer incidence and care have improved substantially over the last few decades, largely due to reductions in smoking, increased cancer screening and advances in treatments such as the development of highly effective conventional chemotherapies, novel targeted agents, immunotherapies, and cellular therapies such as haematopoietic cell transplantation (HCT) and chimeric antigen receptor (CAR) T cell therapy 1

Zhang C, McNeil E, Dressler L, Siman R