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10.1166/jbn.2022.3248 48 ZhaoH.ShanY.MaZ.YuM.GongB

Hexosamine pathway Excess glucose not metabolized via glycolysis can enter the hexosamine pathway, which leads to increased production of uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), which is used for O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins

It is a GH secretagogue and an agonist, meaning it may bind to specific cell receptors and cause a physiological reaction

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Correlations between participants clinical and glycaemic characteristics and performance on the vMWMT, including both the hidden platform phase (time to first move, time to platform and path length) and the probe phase (time spent in the correct quadrant), were evaluated with Pearson or Spearman correlation coefficients, depending upon the normality of variable distributions

Mazdutide is a dual GLP-1R/GCGR agonist without GIP receptor activity making it the only pure GLP-1R/GCGR dual agonist available for comparative receptor pharmacology research