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A drawback of this study was that the dietary intake of -tocopherol, retinol, and -carotene was difficult to estimate based in the intake registration, as diet might influence plasma exogenous antioxidant concentrations

Unfortunately, there is no validated animal model to recapitulate the human patterns of INH-induced liver injury 6

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PMID 17630612

Furthermore, MTHFR knockout mice showed a decrease in methionine level, methionine/homocysteine ratio, dimethylglycine level, and lipid deposition in proximal aorta along with changes in cerebellar pathology, reduced cerebellum, reduced cerebral cortex, and developmental issues ( In conclusion, we identified a novel biallelic non-sense mutation in a single affected individual suffering from severe MTHFR deficiency