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however, many clinical trials fail, and patients experience an unsatisfactory treatment response, likely owing to IC/BPS phenotype heterogeneity and the use of non-targeted interventions

Unlike iron-deficiency anaemia (which is common in pregnancy), B12 deficiency typically presents with a raised mean corpuscular volume (MCV) on full blood count testing

As the dominant G-actin sequestering protein in mammalian cells, TB-500 binds globular actin with high affinity (Kd ~0.5 M) through a sophisticated triple-contact mechanism involving Lys-3, Lys-18, and Lys-38 residues, preventing spontaneous actin polymerization while maintaining a readily mobilizable reservoir for rapid cytoskeletal reorganization

Nat Rev Mol Cell Biol 17:564580

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Glutathione is a tripeptide produced naturally by the liver from three amino acids: cysteine, glycine, and glutamic acid