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B12 plays essential roles in red blood cell formation, DNA synthesis, neurological function, and metabolism of fats and carbohydrates

Due to the random nature of Birdshot label-free quantitative proteomics, protein identification or abundance data are sometimes missing in some samples [38]

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A previous work has demonstrated that HFD induces the production of reactive oxygen species (ROS), lowers the expression of antioxidant genes, and upregulates the expression of proinflammatory cytokines in the RPE (Biswas et al., 2021)

doi: 10.1016/j.phymed.2024.155560 37 JungJLeeSMLeeMJRyuJSSongJHLeeJEet al

They work a step higher up the chain, mimicking the body's own GHRH to signal the pituitary