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Factors such as rectal irritation, lesions, or recent surgery may affect the suitability of this route of administration

in Nature demonstrating that T4 can activate dormant epicardial progenitor cells to generate new cardiomyocytes after myocardial infarction in mouse models remains one of the most cited findings in regenerative medicine peptide research [6]

Phosphorylated Smad2/3 then form a complex with Smad4, which translocates to the nucleus to activate TGF- target genes, including -SMA, collagen, fibronectin, and MMPs [8] (Fig