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One potential explanation is group heterogeneity, in this case an inclusion of participants with different biological backgrounds despite similar clinical presentations, which might lead to a decrease in power to detect changes, especially if these are subtle

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For an excellent full text review of this anatomy and circuits for touch sensing, please see: Thank you to our sponsors AG1 (Athletic Greens): InsideTracker: Thesis: Supplements from Momentous For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Skin, Pain, Pleasure (00:01:50) Protocol 1: Maximizing Motivation (with Dopamine & Pleasure) (00:07:12) Sponsors (00:12:04) Pleasure & Pain, & Skin Sensors (00:18:13) Sensing Touch with Your Brain: Magnification of Feet, Hands, Lips, Face, Genitals (00:22:16) Two-Point Discrimination, Dermatomes (00:28:11) Thoughts & Genes That Make Physical Pain Worse (00:33:45) Expectations, Anxiety, & Pain Threshold (00:40:27) Protocol 2: Cold Sensing Is Relative