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Abdelaziz HM, Elzoghby AO, Helmy MW, Abdelfattah E-Z, Fang J-Y, Samaha MW, et al

In isolated cardiomyocytes from rabbits and mice, treatment with empagliflozin inhibited NHE1 flux, reduced cytosolic Na + and Ca 2+ levels, and increased mitochondrial Ca 2+ levels, likely by direct binding of empagliflozin to NHE1 [143144]