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Foods 13(17):2658

Older patients with depressive and anxiety disorders are susceptible to the age-related acute and chronic brain and physical illnesses, including metabolic, endocrine and neurobiological disorders,1 and are at high risk for cardiovascular, and cerebrovascular comorbidities.2 The significant heterogeneity in geriatric depression results in difficulties in both comparing research findings and identifying biomarkers to establish homogeneous subgroups for depression personalized therapy.3 Since oxidative stress is associated with depression,4 it is reasonable to search for such biomarkers among antioxidant systems, i.e

The same study showed HEM to be more effective than control, NGF, or brain-derived neurotrophic factor (BDNF) alone in enhancing the growth of rat adrenal nerve cells and neurite (axon or dendrite) extension

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Supersulfide Donors as Potential Therapeutic Agents for Oxidative Distress-Related Diseases Both natural and synthetic supersulfide donors, including GSSSG, cysteine trisulfide (CysSSSCys), N-acetylcysteine (NAC) tetrasulfide (NAC-S2), thioglucose tetrasulfide, and inorganic polysulfide sodium salts such as disodium di-, tri-, and tetra-sulfide, can enter inside cells and organs to donate sulfur atoms to intracellular acceptors such as GSH, causing an increase in the supersulfide contents of the cell [100,101] (Figure 8)

The periodic solution in Panel B of Figure 3, GSH(t), is quite stable, fluctuating only between 5,500 and 8,000 M (even though the steady state values vary between 4,151 and 8,516 M)