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In highly glycolytic tumor microenvironments, Treg cells actively take up lactate through monocarboxylate transporter 1 (MCT1), which promotes nuclear translocation of NFAT1 and subsequent enhancement of PD-1 expression

and (4) mTORmembrane engagement and full enzyme activation

Nov 1 2004;22(21):4410-7

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These findings greatly enrich our understanding of the research field of nonhistone writers. Additionally, a significant link has been established between nonhistone lactylation and various non-neoplastic diseases

Vitvitsky V, Thomas M, Ghorpade A, Gendelman HE, Banerjee R: A functional transsulfuration pathway in the brain links to glutathione homeostasis