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NAC treatment provides a source of cysteine, a ratelimiting building block for GSH synthesis, and is known to increase GSH levels in the brain 46

Thus, Notch receptors and ligands are key players in processes that promote the malignant potential of tumors ( DLL3 expression is regulated by the transcription factor ASCL1, which drives neuroendocrine cell differentiation and correlates with tumor-initiating potential ( Figure 2 ) ( Figure 2 In normal tissues, DLL3 expression is typically low or absent

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This induction occurs through the Sb9 promoter region by the transcription factor estrogen receptor (ER) ( Beyond the endogenous regulators, exogenous compounds have also been shown to affect the expression of Sb9

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The B-017-treated group demonstrated recovery of LVEF by day 3, whereas the control group exhibited no change (Fig