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Rights and permissions About this article Cite this article Yoshida, H., Hara, K.Y., Kiriyama, K

The generation of ROS presents a multi-source eruptive pattern, primarily involving three intertwined mechanisms: First, the inflammatory response activates infiltrating neutrophils and macrophages, triggering a violent respiratory burst that produces massive amounts of superoxide anions via NADPH oxidase (NOX), constituting the primary source of local ROS (80)