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Nicotine also increases inflammation

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Gene expression and histological studies of the airway epithelium have demonstrated that both molecular dysfunction and cellular imbalance due to shifting cell composition in the epithelium are common features of most chronic lung diseases, including asthma 3 and chronic obstructive pulmonary disease 4 (COPD)

Authors' contributions CMW, DH, JFT, and GTF contributed to the design of the study, and manuscript preparation

Statistical analysis Comparisons between tobacco product use groups were performed using a one-way analysis of variance for normally distributed continuous variables and chi-squared tests for categorical variables

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