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The pQE-30 bacterial expression plasmid of the U46C mutant of human c-GPX4 was mutated to obtain the D23A mutant

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2016KJZDSF01-05-01)

[3] [4] Less common conditions like Stargardt disease [5] , Bassen-Kornzweig syndrome [6] , Refsum disease [6] [7] , gyrate atrophy (GA) [6] [7] [8] , and cystinosis [9] often intersect with dietary interventions

therefore, a more in-depth exploration into the mechanisms underlying the regulation of the GSH synthesis pathway is needed

The present invention can be used to produce a hybrid polynucleotide by introducing at least a first polynucleotide and a second polynucleotide which share at least one region of partial sequence homology into a suitable host cell