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Dihexa-treated rats quickly regained motor performance equivalent to sham-operated controls, and significantly surpassed those receiving a placebo

Monosomal karyotype: presence of two or more distinct monosomies (excluding loss of X or Y), or one single autosomal monosomy in combination with at least one structural chromosome abnormality (excluding core-binding factor AML)

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As concerns treatment of T!D, longer acting preparations of GABA, co-therapy with GABA receptor agonists, positive allosteric modifiers (59) or complimentary antidiabetic agents (discussed above) could potentially overcome a need for higher GABA doses to achieve efficacy