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These span the range from severe but rare genetically encoded disorders to more common diseases 161,162

These EVs reflect the functional states of their parent cells and participate in both physiological processes and disease mechanisms

PubMed, Kamal, Sanaa, et al

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In htgUGT1A -WT mice, a 17.4-fold CCL2 upregulation and a 10.8-fold TNF- mRNA induction was detected, whereas in the presence of SNPs transcriptional activation of CCL2 (6.4-fold) and TNF- (2.4-fold) was significantly less evident

J., Best, M