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Despite this physical separation, gut microbiota can deeply modulate epithelial cells and the immune system ( de novo synthesized metabolites such as short-chain fatty acids (SCFAs)

References Treibs, A

Chemosphere 283 , 131232 (2021)

To prevent immune failure and cell death, signals that maintain homeostasis and promote cell survival, such as proliferation, differentiation, and maturity, are simultaneously activated