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The administration of high doses of lipoic acid by injection to rats decreased the activity of two biotin-dependent enzymes by about 30%-35% (122), but it is not known whether oral or intravenous lipoic acid supplementation substantially increases the requirement for biotin in humans (123)

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But heres where things get genuinely interesting: this isnt just theoretical biology anymore

This Joint Undertaking receives support from the Unions Horizon 2020 research and innovation programme, EFPIA, JDRF and The Leona M

I think there's more to the pineal gland than we understand