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Elevated ALOX5AP levels are strongly correlated with the presence of M2 macrophages, which are known to promote immune evasion, metastasis, and chemoresistance in ovarian cancer

Bibcode:2020PNAS..11719359Z

A.SharmaS

Tumor-infiltrating immune cells are an essential component of the TIME and can be classified as pro-tumor cells (tumor-associated macrophages and myeloid-derived suppressor cells) and antitumor cells (such as effector T cells and natural killer cells)

441,442 Iron and copper are essential nutrients involved in fundamental biological processes that play crucial roles in health and diseases

Carlson MG, Peterson CG, Venge P: Human eosinophil peroxidase: purification and characterization