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Prospects of synbiotics and therapeutic strategies in Alzheimers disease The search for effective AD interventions increasingly focuses on sophisticated multi-target strategies, exploring gene therapy and combination approaches to simultaneously address core pathologies, amyloid- plaques, neurofibrillary tau tangles, alongside impaired synaptic plasticity, compromised neurovascular function, dysregulated epigenetics, metabolic disturbances (insulin resistance, cholesterol homeostasis), and the GM role in blood-brain barrier integrity [119]

Square skin flaps with a size of 1 mm 2 in the center were taken from the right half flap, and 1 ml of blood was collected via cardiac puncture

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doi:10.1007/s11356-014-3477-4 Condorelli G, De G, Giuffrida S et al (1999) Molecular mechanisms of photosensitization induced by drugs XII

Diabetes Obes Metab 10, 11251127 (2008)

A broad investigation of the HBV-mediated changes to primary hepatocyte physiology reveals HBV significantly alters metabolic pathways