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In summary, CDC42, derived from neural stem cell-derived exosomes, as well as TIGAR, FTO, and IRP2, contribute to PD pathology by regulating iron homeostasis, ferroptosis, fatty acid metabolism, the antioxidant system, and angiogenesis

A secretagogue nudges an upstream node and lets physiology set the resulting IGF-1 level within feedback limits

Following endogenous growth hormone release, insulin-like growth factor-1 (IGF-1) mediates many downstream physiological processes involved in normal growth hormone biology

Alexandre J, Hu Y, Lu W, Pelicano H, Huang P

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