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This would be consistent with the reported BCL-xL upregulation in some hormone-refractory models, 104 the therapeutic efficacy of BCL-xL-targeting BH3 mimetics in RB1-deficient cancers, 106 and the synergistic effects of co-targeting BCL-xL and MCL1 in inhibiting ARv7-positive CRPC

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For instance, data show that cardiovascular diseases, the world's leading causes of death over the past two decades (104, 105), are reversible by diet alone but only when adhering to a healthy, WFPP (especially vegan) diet (106108)

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