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In case of strongly increased ROS concentrations, these types of damage can occur in close proximity to each other on both DNA strands, resulting in DNA DSB (Cannan et al., 2014

Interestingly, upregulation of the protein TTYH3, a calcium-activated chloride channel, was also recently reported in homozygous Cln3 ex7/8/ex7/8 microglia [41], strengthening the hypothesis of a connection between CLN3 loss and TTYH3 induction

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For instance, a posterior communicating artery aneurysm that is compressing the oculomotor nerve might cause double vision

Gradual dose titration significantly reduced side effect severity