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These pathological states and used drugs are common in CKD, but also different according to the CKD stage, which may confound their relationship

Side Effects and Safety Side effects Across preclinical studies and the small human trials published to date (~28 subjects across pilot studies), the reported adverse events stay limited: Mild injection-site irritation (rare) No systemic toxicity at therapeutic doses in published reports Oral administration: mild GI upset in sensitive individuals No immunosuppression, hormonal disruption, or metabolic side effects have been observed

Mitochondria They are tiny organelles found in every cell in the body

Daver N, Assi R, Garcia-Manero G, Ravandi, Borthakur G, Jabbour E, DiNardo CD, Kadia TM, Ning J, Nogueras-Gonzalez G, Pierce S, Kelly M, Zhang W, Gombos DS, Kornblau S, Konopleva M, Cortes J, Kantarjian H, Andreeff M

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Sawicka AK, Hartmane D, Lipinska P, Wojtowicz E, Lysiak-Szydlowska W, Olek RA-O