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In present study, we firstly compared the metabolomics of tumor derived from the first generation of PDX with the primary tumor of patients and found the levels of glycolysis-related and TCA-related metabolites like lactate, pyruvate, and citrate in PDXG1 were significantly lower than the primary tumors

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VerfaillieSCJAdriaanseSMBinnewijzendMAABenedictusMROssenkoppeleRWattjesMPet al

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CB-839 (telaglenastat), a glutaminase inhibitor, blocks tumor glutamine consumption [122]

Intracellular cytokines were stained with anti-PE-mouse Foxp3 antibodies (1:50)