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1 Introduction Intestinal diseases can be broadly classified into several main categories: colorectal cancer (CRC), irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), which encompasses Crohns disease (CD) and ulcerative colitis (UC) (Chang, 2020

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It acts as a potent AMPK activator (similar to metformin), promoting the PI3K/AKT pathway and GLUT4 translocation to reverse systemic insulin resistance [75,76]

Further studies using differentiated neuronal cells are needed to validate and expand these observations

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GHK-Cu is used in cosmetic formulations under various regional regulatory frameworks but is not FDA-approved as a therapeutic