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That said, a significant die-off reaction can also be a signal that detoxification pathways need more supportmore on this below

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Weeks 7, 8, 9, 10 post-STZ injection Result:Lowered Kv2.1/T-ERK ratios relative to vehicle-treated STZ mice

Furthermore, mutagenesis combined with streptomycin resistance (such as streptomycin, gentamicin, and rifampicin) was also developed to improve the fermentation performance of -PL-producing strains [74, 75]