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Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma

The Met hydroxy analogs 2-hydroxy-4-(methylthio) butanoic acid (called HMB or HMTBa) and isopropyl ester of 2-hydroxy-4-(methylthio) butanoic acid (HMBi) have been widely used as a precursor of methionine in ruminant nutrition (Noftsger et al., 2003)

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Together, the blend is hypothesized to offer enhanced therapeutic value in tissue repair models by acting through converging signaling pathways like FAK, eNOS, and VEGF 1-4