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Compared with traditional meta-analysis using linear mixed effect models, MR-BRT relaxes the assumption of a log(linear) relationship between exposure and risk, incorporates between-study heterogeneity into the uncertainty of risk estimates, handles estimates reported across different exposure categories, automatically identifies and trims outliers, and systematically tests and adjusts for bias due to study designs and characteristics

The only meaningful difference was that fewer women in the e-cigarette group had children with low birthweight (weighing less than 2,500 grams)

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As the study did not involve primary data collection, randomization and blinding, data exclusions were not relevant to the present study, and, as such, no data were excluded and we performed no randomization or blinding

They found that those who vape a popular pastime among teens and 20-somethings are 22% more likely to develop prediabetes than those who had never partaken