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Another Phase I trial (NCT04629404) was conducted on early-stage PD patients to assess pharmacokinetics, pharmacodynamics, and safety of LY03003, demonstrating well tolerability and promising pharmacodynamic effects, suggesting its suitability for continuous dopaminergic stimulation 141

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confirmed that the alteration of this enzymes activity led to the overproduction of damaging free radicals and eventually oxidative damage to neuron [200]

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