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Kowalski M, Entwistle J, Cizeau J, Niforos D, Loewen S, Chapman W, et al

10.1016/j.heliyon.2024.e27074 [DOI] [PMC free article] [PubMed] [Google Scholar] 250.Tu, C.-M

Next, the mixture was treated with 1 ml of 7 mM N -(1-Naphthyl) ethylenediamine and 17 mM p -aminobenzene sulfonic acid for 20 min at room temperature

Published clinical trial data describe weekly dose-escalation protocols ranging from sub-milligram to low-milligram levels in controlled study populations

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While SOD2 converts superoxide radicals to H 2 O 2 , the deficiency in downstream H 2 O 2 -detoxifying enzymes (CAT and peroxiredoxins) potentially leads to H 2 O 2 accumulation, exacerbating oxidative stress (Chen et al., 2008)