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Various inherited and lifestyle factors contribute to vitamin B12 deficiencies that impair such fundamental life processes as recycling of homocysteine, a potentially toxic metabolite, nerve cell signaling, mood and memory management, and healthy gene regulation (epigenetics), from pregnancy through old age

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MitoE, a form of Vitamin E attached to the TPP cation, has been documented in vitro to promote mitochondrial biogenesis, protect mitochondria and whole cells from oxidative stress, and be much more effective than non-targeted equivalents [98,99,100,101]

doi: 10.1002/14651858.CD013853.pub2 62 WgbergS.StlnackeB

Although it is difficult to conclude that ROS are the primary cause of apoptosis in this context, it is more likely that both DPI and MitoQ cause irreversible damage to OXPHOS in MNA cells (23, 31)

Self-assembling peptide amphiphile promotes plasticity of serotonergic fibers following spinal cord injury