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[The Working Group noted that these studies may be of limited relevance to the key characteristic of carcinogens induces chronic inflammation.] Altered cytokine levels TNF levels, measured via ELISA, in the brain tissue of Swiss albino mice exposed subcutaneously to aspartame in saline solution at doses of 22.5 or 45 mg/kg were elevated relative to levels in controls exposed intraperitoneally to saline solution at 0.1 mL/mouse (Abdel-Salam et al., 2012a)

doi: 10.1080/21678421.2023.2239292 50

Accordingly, during an immune challenge, substance P produced by immune and non-immune cell types can function as a potent chemoattractant and promote the inflammatory responses of a diverse range of cells including macrophages, dendritic cells, lymphocytes and eosinophils (OConnor et al., 2004)

Glutathione tn ti c hai dng l dng kh (GSH) v dng oxy ha (GSSG) nhng phn ln lng ca n trong c th dng kh, hai dng ny c th chuyn i qua li cho nhau